C 300 4MATIC vs. E 350 4MATIC: Which Mercedes-Benz Sedan is Right for You?

When comparing two of Mercedes-Benz's refined sedans, the 2026 C 300 4MATIC and the E 350 4MATIC, drivers across Quebec encounter two distinct interpretations of luxury, performance, and technology. The C-Class serves as a dynamic compact luxury sedan, while the E-Class offers a more spacious midsize platform with enhanced capability.

Understanding the differences between these models helps drivers make an informed choice. From the agile handling of the C-Class to the additional interior space of the E-Class, both vehicles deliver the sophistication and innovation Mercedes-Benz is known for.

Powertrain and Performance

The 2026 C 300 4MATIC Sedan features a 2.0L turbocharged inline-4 engine paired with a 48V mild hybrid system. This powertrain delivers 255 hp and 295 lb-ft of torque, channeled through a 9G-TRONIC 9-speed automatic transmission and standard 4MATIC all-wheel drive. Acceleration from 0–100 km/h occurs in 6.0 seconds.

The E 350 4MATIC Sedan also features a 2.0L turbocharged inline-4 engine with mild hybrid technology. Output matches the C-Class at 255 hp @ 5,800 rpm and 295 lb-ft of torque @ 2,000–3,200 rpm. The integrated starter-generator provides an additional 20 hp and 148 lb-ft of boost torque for enhanced responsiveness. Power flows through a 9G-TRONIC 9-speed automatic transmission with standard 4MATIC all-wheel drive. Acceleration from 0–100 km/h takes 6.2 seconds.

Both sedans benefit from mild hybrid technology, which provides efficient start/stop functionality, energy recuperation during braking, and brief electric boost for improved efficiency. The C-Class holds a slight edge in acceleration, while the E-Class offers additional boost torque from its updated mild hybrid battery.

Interior Space and Comfort

The C 300 4MATIC Sedan offers seating for five passengers in a compact luxury package. Front headroom measures 1,041 mm, with 1,059 mm of front legroom and 1,430 mm of shoulder room. Rear passengers enjoy 955 mm of headroom, 914 mm of legroom, and 1,411 mm of shoulder room. Cargo capacity is rated at 455 litres, with 40/20/40-split folding rear seats for added versatility.

The E 350 4MATIC Sedan offers seating for five passengers in a midsize luxury package. The longer wheelbase (2,961 mm versus 2,865 mm) translates to increased rear passenger space. Mercedes-Benz notes that rear passengers benefit from a two-centimetre longer wheelbase compared to the previous generation, with increases of 10 mm and 17 mm in knee room and maximum legroom. Rear elbow width measures an impressive 1,519 mm—approaching S-Class levels of comfort. Cargo capacity is rated at 540 litres, providing 85 litres more than the C-Class.

Both sedans feature Mercedes-Benz's signature attention to detail, with high-quality materials, available Nappa leather upholstery, and customizable ambient lighting. The C-Class offers a driver-focused cockpit with a portrait-style 11.9-inch multimedia touchscreen and a 12.3-inch digital instrument cluster. The E-Class offers the optional MBUX Superscreen, with an expansive glass surface extending from the instrument cluster to the central display.

Technology and Connectivity

Both the C 300 4MATIC and E 350 4MATIC Sedans feature the third-generation Mercedes-Benz User Experience (MBUX) infotainment system, offering voice control via "Hey Mercedes," wireless Apple CarPlay and Android Auto, and over-the-air software updates. The C-Class includes a 12.3-inch digital instrument cluster and an 11.9-inch central media display.

Standard connectivity features include:

• SiriusXM satellite radio
• High-definition radio
• Advanced navigation with live traffic updates
• Smartphone-based digital key pre-installation
• Wireless charging (C 300 4MATIC)

Driver assistance features are comprehensive in both models. The C 300 4MATIC includes Active Brake Assist, Blind Spot Assist with Exit Warning, PARKTRONIC with Active Parking Assist, a rearview camera, and ATTENTION ASSIST. The E-Class adds available ATTENTION ASSIST with distraction detection, using an interior camera to detect when the driver's eyes are not focused on the road.

Fuel Economy and Efficiency

The 2026 C 300 4MATIC Sedan achieves fuel economy ratings of 10.0 L/100 km in the city and 7.1 L/100 km on the highway, reflecting its efficient 2.0L turbocharged engine and mild hybrid system. The fuel tank capacity is 66 litres.

The E 350 4MATIC Sedan achieves fuel economy ratings of 10.0 L/100 km in the city and 7.2 L/100 km on the highway. The fuel tank capacity is also 66 litres. Despite its larger size and additional passenger space, the E-Class delivers nearly identical fuel efficiency to the C-Class.

Both sedans maximize efficiency through intelligent energy recuperation, ECO Start/Stop systems, and optimized aerodynamics.

Handling and Driving Dynamics

The C 300 4MATIC Sedan features a 4-wheel independent suspension with a 4-link front and 5-arm multilink rear setup, paired with selective damping for a balance between comfort and responsiveness. The turning circle measures 11.5 metres, making the C-Class easy to manoeuvre in tight spaces.

The E 350 4MATIC Sedan features a 4-wheel independent suspension with Agility Control selective damping, using a 4-link front and 5-arm multilink rear configuration. The turning circle measures 12.0 metres. The optional Technology package adds AIRMATIC air suspension with ADS+ continuously adjustable damping and rear-axle steering (4.5 degrees), which can reduce the turning circle by up to 90 centimetres for improved manoeuvrability.

Both sedans benefit from 4MATIC all-wheel drive, which continuously adapts torque distribution to maximize traction and stability. The C-Class emphasizes nimble, sport-sedan dynamics, while the E-Class offers a more refined, comfort-oriented ride with available air suspension.

Exterior Design and Dimensions

The C 300 4MATIC Sedan measures 4,751 mm in overall length, 1,820 mm in width (without mirrors), and 1,437 mm in height, with a wheelbase of 2,865 mm. Standard equipment includes 18-inch multispoke wheels, LED High Performance Lighting, and a chrome Star-pattern grille. The C-Class's lowered stance and sculpted lines emphasize its athletic character. Curb weight is 1,770 kg.

The E 350 4MATIC Sedan measures 4,949 mm in overall length, 1,880 mm in width (without mirrors), and 1,469 mm in height, with a wheelbase of 2,961 mm. Standard equipment includes 18-inch 5-spoke wheels (225/55R18 all-season runflat tires), LED High Performance Lighting, and a distinctive black panel connecting the radiator grille with the headlamps. Curb weight is 1,900 kg.

Both sedans feature full LED lighting, rain-sensing wipers, and power-folding side mirrors. The E-Class's larger dimensions provide additional interior space and road presence, while the C-Class's compact footprint makes it ideal for urban driving and tight parking situations.

Key Takeaways

Which Sedan is Right for You?

Choosing between the C 300 4MATIC and E 350 4MATIC Sedans depends on your priorities and lifestyle. The C-Class excels as a compact luxury sedan that delivers engaging driving dynamics, efficient performance, and advanced technology. It's ideal for drivers who value agility, fuel economy, and a sport-sedan character, particularly those navigating urban environments.

The E-Class offers additional interior space, approaching S-Class levels of rear-seat comfort. With 85 litres more cargo capacity and a longer wheelbase, it suits drivers who prioritize passenger comfort and versatility. The available MBUX Superscreen and optional AIRMATIC air suspension with rear-axle steering provide an enhanced technology and comfort experience.

Both sedans share Mercedes-Benz's focus on safety, technology, and craftsmanship. The identical powertrain and similar fuel economy mean your choice comes down to size preference and intended use.

Experience the Difference at Mercedes-Benz Laval

Ready to explore the differences between the C 300 4MATIC and E 350 4MATIC Sedans? Our team at Mercedes-Benz Laval is here to help. Schedule a test drive to experience both models and discover which sedan best fits your needs and driving style. Contact us today.